Using affinity propagation for identifying subspecies among clonal organisms: lessons from M. tuberculosis

Characterization of Mycobacterium orygis as M. tuberculosis Complex Subspecies

The oryx bacilli are Mycobacterium tuberculosis complex organisms for which phylogenetic position and host range are unsettled. We characterized 22 isolates by molecular methods and propose elevation to subspecies status as M. orygis. M. orygis is a causative agent of tuberculosis in animals and humans from Africa and South Asia.

Subspace clustering using affinity propagation

This paper proposes a subspace clustering algorithm by introducing attribute weights in the affinity propagation algorithm. A new step is introduced to the affinity propagation process to iteratively update the attribute weights based on the current partition of the data. The relative magnitude of the attribute weights can be used to identify the subspaces in which clusters are embedded. Experi...

RecQ helicases: lessons from model organisms

RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication, and that proteins involved in the S-phase checkpoint are a principal defence against such instability. Cells that lack functional RecQ helicases exhibit phenotypes consistent with ...

Self-grafting a simple method for vegetative propagation of apple clonal rootstocks

Prospects for global health: lessons from tuberculosis.

Preventable diseases continue to afflict billions of people worldwide in both rich and poor countries. With regard to tuberculosis (TB), much has been learned over the past century about Mycobacterium tuberculosis, the responsible infectious agent, and its medical treatment and cure. TB is, however, an old disease currently making a resurgence at the global level. An estimated one third of t...